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dc.contributor.authorBastle, Ryan M.en_US
dc.contributor.authorNeisewander, Janet L.en_US
dc.date.accessioned2018-10-30T07:01:52Z
dc.date.available2018-10-30T07:01:52Z
dc.date.issued2016
dc.identifier.isbn978-953-51-2492-4en_US
dc.identifier.otherHPU3160494en_US
dc.identifier.urihttp://lib.pyu.edu.vn/handle/123456789/1979
dc.description.abstractGene expression and inheritance are not only a function of the DNA code, but also epigenetic mechanisms that regulate DNA accessibility, transcription, and translation of the genetic code into a functional protein. Epigenetic mechanisms are invoked by life experiences, including stress and exposure to drugs of abuse, and the resulting changes in gene expression can be inherited by future generations. This chapter highlights recent research demonstrating epigenetic changes in response to drug exposure with a focus on three different mechanisms: DNA methylation, histone modification, and noncoding RNAs. We briefly describe each of these mechanisms and then provide key examples of drug-induced changes involving these mechanisms, as well as epigenetic manipulations that alter effects of drugs. We then review cutting-edge technologies, including viral-mediated gene transfer and gene editing, that are being used to manipulate epigenetic processes with temporal and cell-type specificity. We also describe and provide examples of intergenerational epigenetic modifications, a topic that has interesting implications for how addiction-related traits may be passed down across generations. Finally, we discuss how this research provides a greater understanding of drug addiction and may lead to novel molecular targets for preventions and interventions for drug abuse.en_US
dc.language.isoenen_US
dc.publisherINTECH Open Access Publisheren_US
dc.subjectMedicineen_US
dc.subjectDNA methylationen_US
dc.subjectHistone modificationen_US
dc.subjectNoncoding RNAen_US
dc.subjectCocaineen_US
dc.subjectAlcoholen_US
dc.titleRecent Advances in Drug Addiction Research and Clinical Applications. Chapter 2: Epigenetics and Drug Abuseen_US
dc.typeBooken_US
dc.size949KBen_US
dc.departmentEducationen_US


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