High content screening identifies a role for Na+ channels in insulin production
MetadataShow full item record
Insulin production is the central feature of functionally mature and differentiated pancreaticβ-cells. Reduced insulin transcription and dedifferentiation have been implicated in type 2 diabetes, making drugs that could reverse these processes potentially useful. We have previously established ratiometric live-cell imaging tools to identify factors that increase insulin promoter activity and promote β-cell differentiation.
- Education